Our latest article has been published in Cell Death & Differentiation. The study focuses on the molecular mechanism of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) in highly aggressive breast tumors with Centrosome amplification (CA). We demonstrated, for the first time, that TACC3 forms distinct functional interactomes regulating different processes in mitosis and interphase to ensure proliferation and survival of cancer cells with CA.
Read the article here.
We participated in the AACR conference with three distinct poster presentations.
Ozgur Sahin was recognized for his work and article, “Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer,” published by Nature Communications Nov. 2, 2023. Read more…
https://hollingscancercenter.musc.edu/news/archive/2024/02/06/hollings-researchers-demonstrate-restoring-effectiveness-of-breast-cancer-drug-after-resistance
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