OZGUR SAHIN LAB – Molecular Mechanisms of Drug Resistance and Metastasis

A NEW postdoc position is immediately available in our lab

Posted onAugust 12, 2021September 18, 2021Leave a comment

If you are interested in working at the intersection of mechanisms of drug resistance, metastasis and drug discovery, please apply via: https://www.nature.com/naturecareers/job/postdoctoral-fellow-in-cancer-research-university-of-south-carolina-columbia-sc-746191

Our R01 grant is funded by the NIH/NCI

Posted onAugust 12, 2021August 12, 2021Leave a comment

Our R01 grant entitled “Inhibiting tumor growth and metastasis in highly aggressive breast cancers with centrosome amplification” has been funded. In this exciting project, we will target highly aggressive breast cancers with our newly developed inhibitor.

A postdoctoral research fellow position is immediately available in our lab

Posted onMay 3, 2021May 15, 2021Leave a comment

Details of the position and how to apply are here.

Our collaborative paper with Halozyme, Inc has been published in Cancer Research

Posted onMay 3, 2021May 14, 2021Leave a comment

This study introduces endogenous ADA2 expression as a prognostic factor and PEGADA2 as a novel immunotherapy for cancer. Read the article here.

Dr. Sahin gave a talk on “Targeting LOX in chemoresistance and developing novel LOX inhibitors” at the ACS Mini Symposium

Posted onFebruary 21, 2021February 21, 2021Leave a comment

Dr. Sahin co-organized a Mini Symposium with Dr. Taru Muranen (Dana-Farber Cancer Institute) and Rebeca San Martin (University of Tennessee, Knoxville) which was hosted by Joe Cotter from the American Cancer Society – February 17, 2021. The Mini Symposium was Read More …

Dr. Sahin presents “From mechanisms of resistance to drug discovery” at IBG Seminer Series

Posted onFebruary 21, 2021February 21, 2021Leave a comment

Dr. Sahin presented our recent work on how we take genome/transcriptome-wide approaches to identify regulators of drug resistance, identify mechanisms of resistance and develop novel drug candidates on Feb 12, 2021 at the Seminar Series of Izmir Biomedicine and Genome Read More …

Dr. Sahin presents a “Lightning Talk” at AACR Virtual Special Congress

Posted onJanuary 20, 2021January 22, 2021Leave a comment

AACR Virtual Special Congress, “The Evolving Tumor Microenvironment in Cancer Progression; Mechanisms and Emerging Therapeutic Opportunities” – January 11-12, 2021, brought together experts from diverse fields to thoroughly explore and discuss the topic. Dr. Sahin gave a “Lightning Talk” on Read More …

Dr. Sahin gives a talk at the Multidisciplinary Cancer Research Congress

Posted onJanuary 20, 2021January 20, 2021Leave a comment

Dr. Sahin gave a talk entitled “From mechanisms of drug resistance to drug discovery” at the 8th Multidisciplinary Cancer Research Congress held by Istinye University, Istanbul – January 16, 2021. The talk was well received by the audience with multiple Read More …

Dr. Sahin presents our project on targeting LOX in TNBC at the National NIGMS IDeA PI Meeting

Posted onSeptember 22, 2020December 15, 2020Leave a comment

Our project aiming at overcoming chemotherapy resistance in TNBC via targeting lysyl oxidase (LOX) was chosen for presentation at National NIGMS IDeA Program Virtual Meeting – September 22, 2020. Our discovery of this novel drug resistance mechanism was recently published Read More …

Our new paper is published in Nature Communications

Posted onMay 15, 2020January 20, 20211 Comment

Our latest article has been published in Nature Communications. The study focuses on the identification of lysyl oxidase (LOX) protein as a major chemotherapy resistance modulator in triple negative breast cancer. We showed that targeting LOX overcomes chemoresistance in TNBC. Read More …