Ozgur Sahin (PI, Professor)
Ozgur Sahin is a Professor and SmartState Endowed Chair in the Department of Biochemistry & Molecular Biology and Hollings Cancer Center at Medical University of South Carolina (MUSC), Charleston, SC. He earned his Ph.D. degree (summa cum laude) in cancer systems biology/cell biology at German Cancer Research Center (DKFZ) and the University of Heidelberg in 2008. Previously, he held positions as a research team leader in the Division of Molecular Genome Analysis at DKFZ, as a research faculty in the Department of Molecular & Cellular Oncology at the University of Texas MD Anderson Cancer Center (MDACC), as an assistant professor in the Department of Molecular Biology & Genetics at Bilkent University and as an associate professor in the Department of Drug Discovery & Biomedical Sciences at University of South Carolina (UofSC). Dr. Sahin was an EMBO-YIP Installation Grant Awardee and later American Cancer Society Research Scholar. Dr. Sahin published nearly 70 peer-reviewed papers in the field of cancer research in high impact international journals (e.g. PNAS, Cancer Cell, Nature Communications, Cell Research, Molecular Systems Biology, Cancer Research and Oncogene, etc.) and filed multiple patent applications. To date, he has received multiple funding (as PI) for his research from the EMBO, European Union FP7 Program, TUBITAK, American Cancer Society and the National Institutes of Health. Dr. Sahin has received many awards, including TUSEB Aziz Sancar (Nobel Laureate) Science Incentive Award from the Health Institutes of Turkey, Outstanding Young Scientist (GEBIP) Award from Turkish Academy of Sciences, USC Research Excellence Award, and MUSC Research Excellence Award.
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HM Lee (Research Assistant Professor)
HM Lee is a research assistant professor in the Department of Biochemistry and Molecular Biology and Hollings Cancer Center at the Medical University of South Carolina. With a rich interdisciplinary background, his enduring research pursuits have been centered on advancing therapeutics for various human diseases, notably breast cancer and kidney cancer. He has published several major breakthroughs (full list: https://tinyurl.com/4bacr2u7). Transitioning from Memphis, TN, where he conducted pioneering studies on chemotherapeutic combinations, he recently aligned his expertise with the esteemed laboratory of Dr. Ozgur Sahin in 2024. Prior to this, he conducted extensive research aimed at unraveling therapeutics for neurodevelopmental disorders, yielding multiple publications and securing two patents. His transition to oncology signifies a strategic shift in his translational research endeavors. His research focus is to address critical gaps in our understanding of epi/genetic mechanisms of drug responses & resistance and to contribute to the development of innovative therapeutic strategies.
Ozlem Sener Sahin (Lab Manager)
I obtained my bachelor degree in Biology from the Department of Biology at Erciyes University and completed my MSc degree in Teaching Biology at Baskent University. Later on, I started my “Diplomarbeit” at the Department of Biology at University of Heidelberg; however, I had to quit my study due to maternity leave. During my education, I actively participated in biological research, especially in cancer research. I worked as a part-time research assistant at German Cancer Research Center (DKFZ) where I mainly focused on functional genomics studies in the identification of novel oncogenes. Then, I worked at Bilkent University and the University of South Carolina as a research lab manager/technician before joining MUSC. I have been actively participated in breast cancer research to identify novel drug targets overcoming resistance to standard chemo- or targeted therapy agents. I have extensive experience in breeding genetically engineered mice, genotyping, xenograft generation, oral, IP and IV injections for drug treatments as well as mice surgery. In addition to bench work, I have long-term experience in ordering lab material, arranging shipments, organizing laboratory and generating and updating animal and biosafety protocols.
Metin Cetin (Postdoctoral Fellow)
I graduated from the Department of Biology at Istanbul University in 2009. I obtain my Master’s degree in 2013 and PhD degree in 2019 from the Molecular Biology and Genetics Department at Gebze Technical University. My PhD project was to develop ROR1 monoclonal antibodies and to determine the functions of ROR1 in hepatocellular carcinoma. I have gained hands-on experience in generation of monoclonal antibodies with hybridoma technology, CrispR/Cas9, ChIP-seq, molecular cloning, generating stable cell lines with lentiviral based shRNA/ORF, exosomes and BioID during post-graduate studies. In addition, I have intensive experience in cell sorting by flow cytometry and imaging in confocal microscopy. I have a long-lasting interest in the mechanisms of drug resistance and metastasis. Since August 2021, I have been working on understanding of the mechanisms of drug resistance in the context of tumor microenvironment and drug development for better cancer treatment as a Postdoctoral Fellow in Sahin Lab.
Mustafa Emre Gedik (Postdoctoral Fellow)
I am a Postdoctoral Fellow at Sahin Lab in the Department of Biochemistry & Molecular Biology at Medical University of South Carolina (MUSC). I have a PhD degree in Tumor Biology and Immunology from Hacettepe University Cancer Institute Department of Basic Oncology. I also earned Organisation for PhD Education in Biomedicine and Health Sciences in the European System (ORPHEUS) Label based on my PhD performance. My research interests include signaling pathways in cancer, targeted therapies against cancer, tumor immunology and microenvironment. Since June 2022, I have been working on inhibition of metastasis in highly aggressive breast cancer and elucidating the contribution of immune system to targeted therapy resistance in breast cancer.
Burge Ulukan Altun (Postdoctoral Fellow)
I graduated from Genetics and Bioengineering Department at Yeditepe University in 2015. Then, I completed my MSc degree in Biotechnology at Yeditepe University in 2017. I have a PhD degree in Cellular and Molecular Medicine from Koc University. During my graduate studies, I learned a lot of molecular techniques such as primary cell isolation, genetic and epigenetic manipulation techniques including CRISPR systems, pyrosequencing, and precision cut ex-vivo slices technology. My research interests revolve around understanding of the signaling pathways involved in cell-cell and cell-ECM interactions and seeking novel cancer-specific biomarkers.
Ozge Saatci (Postdoctoral Fellow)
I am a Postdoctoral Fellow working on mechanisms of drug resistance and metastasis in cancer. I graduated from the Department of Chemical Engineering at METU in 2013 (ranked 3rd in university), and earned my MSc degree in cancer cell biology and drug resistance at Bilkent University in 2016. Then I earned my PhD degree at MUSC in 2023. I have extensive training in basic and advanced molecular, cellular and translational cancer research, involving the generation and use of various in vitro cell systems, as well as the use of state-of-the-art mouse models of breast cancer. My postdoctoral studies focus on elucidating the role of key proteins in resistance to chemotherapy, hormone therapy and targeted therapy in different subtypes of breast cancer.
Kubra Calisir (Graduate Student)
I am a PhD candidate at Sahin’s Lab. I graduated from the Department of Biology at Middle East Technical University in 2020. Then I earned my MSc degree at Bilkent University in 2022. In my MSc thesis project, I developed an app to predict breast cancer subtypes using machine learning. I have extensive training in bioinformatics and analysis of various datasets such as microarray, RNA-seq, and single-cell RNA-seq. My Ph.D. project focuses on elucidating the role of proteins in DNA damage and chromosomal instability and their effects on the immune system in solid tumors.
Sezen Guntekin Ergun (Visiting Scholar)
I graduated from the Department of Biology at Gazi University in 2004. I obtain my master’s degree in 2007 from the Pharmaceutical Microbiology at Gazi University. I have a PhD. Degree in Basic Biotechnology Institute. Then I worked as a postdoc at Middle East Technical University on the drug screening in breast cancer and hepatocellular carcinoma (HCC). Currently I am working as a lecturer at Department of Medical Biology at Hacettepe University. My main interests include novel drug discovery and understanding the mechanism of those drugs in breast cancer and HCC.
Recently, I am a visiting scholar at Dr. Sahin’s lab in the Department of Biochemistry and Molecular Biology at MUSC focusing on immunotherapy in breast cancer.
Mustafa Ozaydin (Summer Intern)
I graduated from the Department of Molecular Biology and Genetics at Istanbul Technical University in 2024. From 2021 to 2024, I served as an undergraduate research assistant at Koç University’s Translational Medicine Research Center. During this period, my research focused on CRISPR-Cas9 mediated gene regulation strategies in breast cancer cell lines. In the summer of 2023, I conducted research at Johns Hopkins University’s Miller Research Building, exploring the application of prime editing for generating and investigating the role of specific mutations in rare diseases.